The Sierra is built on a stiff platform for a smooth ride and sharp handling. The GMC Sierra shares platforms with the Chevy Silverado but its exterior styling is quite different.

Sierra interiors offer a choice of two dashboard styles. The traditional layout, called pure pickup, has a driver-oriented dash layout with larger switchgear and door handles designed for work gloves. The pure pickup interior includes a 40/20/40 split front bench seat with the center section folding down to provide a large storage compartment and wide armrest. The other style in the luxurious Sierra SLT is similar to what's found in the latest luxury SUVs, with two front bucket seats separated by a fixed center console. This design places audio and ventilation system controls more easily within reach of the front-seat passenger, which may or may not be a spouse, and it offers a navigation system and storage compartments.