Why it's on the list: Fuel; Depreciation
The Mercedes-Benz E350 Coupe is the second most cost-efficient car from the automaker on our list of cars that will bleed you dry. Still a car that will run up the dollar signs, the E350 Coupe only has two variables that make it so expensive. Fuel is the first issue, thought it isn't as expensive when compared to the depreciation value of the car. As soon as this car is placed into your hands, don't think for a second that you will see that money again. If you ever decide to resell this car, you're looking at a significant loss that turns many people away from purchasing it in the first place.