2006 Isuzu I-350

  • 2006 Isuzu I-350 LS Crew Cab Pickup

    LS Crew Cab Pickup

    • MAX MPG
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    • ENGINE
      3.5L I5
    • MSRP
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2006 Isuzu I-350 Review

Has a solid 75,000-mile, seven-year powertrain warranty.

Reviewed by Automotive on


The 2006 Isuzu i-350 is a midsize pickup truck that is part of the i-Series manufactured by General Motors. The Isuzu i-350, along with its smaller version, the i-280, was introduced at the New York International Auto Show in 2005, and it went into production later the same year. The 2006 Isuzu i-350 replaces the Isuzu Hombre, which was discontinued in 2005. Like the Hombre, the i-350 shares the same platform as other midsize pickups sold by General Motors.

The i-Series dominates a significant percentage of the pickup truck segment in Thailand, but its performance in the United States didn't measure up. However, the 2006 Isuzu i-350 comes with one particular feature that makes it different from the rest: its 75,000-mile, seven-year powertrain guarantee.

The Range

Body Style: Four-door, crew-cab pickup
Engine: 3.5-liter Atlas L52 five-cylinder engine
Transmission: Five-speed manual, four-speed automatic
Model: Isuzu i-350 LS

What's New

The 2006 Isuzu i-350 is in its first model year, replacing the Isuzu Hombre after a five-year hiatus. Along with the i-280, the i-350 is part of Isuzu’s reentry into the midsize pickup truck segment in the U.S. market.


The exterior of the 2006 Isuzu i-350 is based on the GMT 355 platform, a joint effort by engineers from General Motors and Isuzu. The distinctive feature of the 2006 Isuzu i-350 is its chrome grille that gives a little bit of elegance to an otherwise bland-looking pickup. The Isuzu logo is emblazed on a crossbar over the grille. However, the dividers between the double-deck headlights are not in line with the crossbar, which might seem a little odd to some customers. Overall, the 2006 Isuzu i-350 looks good from the front, but its exterior design quality is average.

The Isuzu i-350 comes with four conventional front-hinged doors, so the rear doors open independently of the front. Fifteen-inch aluminum wheels are standard, and the optional Limited Package adds a moonroof and sliding rear window.


The 2006 Isuzu i-350 has a comfortable, but subpar, interior. The steering wheel has a tilting function, and the front and rear seats provide adequate comfort. Interior features include power windows, cruise control, power accessories, keyless entry, and front bucket seats. The Luxury Package offers additional options, such as a six-CD changer, locking rear differential, side curtain airbags, sliding rear window, moonroof, auto-dimming rearview mirror, leather upholstery, and dual power heated seats.

Performance & Handling

The 2006 Isuzu i-350 is fitted with an inline 3.5-liter five-cylinder engine with 220 hp and 225 lb-ft of torque. The engine is mated to a five-speed manual as standard, but a four-speed automatic gearbox is also available. The Isuzu i-350 comes with Insta-Trac four-wheel drive, which permits shifting between 2WD and 4WD High at the touch of a button while under way.

In terms of performance, the five-cylinder engine under the hood of the 2006 Isuzu i-350 delivers decent throttle response at first, but it reaches its limit rather quickly. The four-speed automatic is quite outdated, which was introduced two decades ago, and it shows in the performance of the truck. The ladder frame construction gives the truck a solid feel on flat surfaces as well as moderately bumpy ones. Overall, the 2006 Isuzu i-350 delivers the performance of a decent pickup truck but nothing spectacular.

Isuzu paid extra attention to the cabin insulation, which results in a considerably quiet ride. The comfortable steering wheel also makes things easier for the driver. The truck has a payload capacity of 1120 pounds, which is not bad for its category. However, its towing capacity of 4000 pounds is below average.


The 2006 Isuzu i-350 is fitted with standard safety equipment such as four-wheel anti-lock brakes. Roof-mounted side curtain airbags are offered as an option. The Isuzu i-350 earned decent scores in government crash tests; it earned a five-star rating in side-impact safety for rear passengers, and four out of five stars in frontal-impact safety for front and rear passengers and side-impact safety for front passengers.

EPA Fuel Economy

Isuzu i-350 LS: 16/21 mpg city/highway

You'll Like

  • Decent handling
  • Comfortable interior
  • The longest powertrain guarantee in its segment
  • Decent safety ratings

You Won't Like

  • Low-quality materials
  • Outdated automatic gearbox

Sum Up

Has a solid 75,000-mile, seven-year powertrain warranty.

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